A daily-updated life-science feed prioritizing spatial multi-omics and spatial biology, with synthetic biology, cancer, AI-driven biology, immunology, organoids, organ-on-a-chip, and host–pathogen research — pulled automatically from Nature, Cell, Science, Cancer Discovery, bioRxiv, and arXiv.
140 papers from the last 14 days · last updated 9 Sep 2026, 15:08 UTC
Science (New York, N.Y.) · 2026-09-03
· 5 media mentions
Focus: Psilocybin prevents chemotherapy-induced peripheral neuropathy through mitochondrial trafficking preservation.
Chemotherapy-induced peripheral neuropathy (CIPN) is a disabling, often irreversible toxicity that affects millions of patients, limits life-saving cancer therapy, and lacks proven treatment.
In this work, we show that as little as two doses of psilocybin before chemotherapy durably prevented the onset of CIPN across platinum- and taxane-based models, including repeated…
Science (New York, N.Y.) · 2026-09-03
· 5 media mentions
Focus: Tumor-derived antioxidants suppress immunity by depriving T cells of reactive oxygen species.
Reactive oxygen species (ROS) promote genomic instability and fuel oncogenic signaling in cancer, but antioxidant therapies have so far failed to improve, or worsen, cancer outcomes.
Emerging data suggest that T cells depend on ROS for signal transduction.
Focus: Explainable deep learning improves human mental models of self-driving cars.
Self-driving cars increasingly rely on deep neural networks to achieve human-like driving 1-3.
The opacity of these black-box planners makes it challenging to accurately anticipate when they will fail 4-6 , with potentially catastrophic consequences 7-9.
Focus: Cross-species single-cell atlas of the striatum defines cell-type and subregion disease vulnerabilities.
The striatum is critical for decision-making, movement, and reward processing, functions achieved through subregional cellular and molecular specialization.
Striatal cell types and subregions are differentially implicated in neurodegenerative and neuropsychiatric disorders, but the mechanisms underlying these vulnerabilities are poorly understood.
Focus: Designing physics experiments with artificial intelligence.
Progress in physics has long been driven by ingenious experiments conceived by human experts.
Recently, design methods driven by artificial intelligence (AI) have begun to move beyond tuning a handful of parameters to proposing entirely new experimental layouts.
Focus: Current therapeutic landscape and future treatment perspectives of MASH.
Metabolic dysfunction-associated steatohepatitis (MASH), the progressive form of metabolic dysfunction-associated steatotic liver disease (MASLD), is a heterogeneous and systemic disease that confers risk not only for cirrhosis and…
Focus: Predicting cellular responses to perturbation across diverse contexts with State.
While machine learning models offer potential for predicting transcriptomic effects of perturbation, they currently struggle to generalize across cellular contexts.
Here, we introduce State, a machine learning model that predicts perturbation effects while accounting for cellular heterogeneity within and across experiments.
Focus: Identification of the tendon/ligament stem cell in mice and humans.
Ligamentum flavum (LF) hypertrophy resulting in spinal cord compression is a key cause of lumbar spinal stenosis (LSS).
There are no medical therapies for LSS, in part because the identity of the tendon/ligament stem cell (TLSC) mediating LSS remains unclear.
Updated daily from published papers in the feed; preprints are excluded. Candidates come from the last 15 days and are ranked using recent Google News coverage plus 7-day public Bluesky activity and citation growth reported by Europe PMC, with spatial biology prioritized. X and LinkedIn are not counted because reliable public paper-level data are unavailable. Attention indicates current interest, not research quality.
Batardiere, M., Ibanez-Rios, M. I., Khellaf, A., Dianati, E., Diwan, S.-S., Pelloux, M., Archambault-Marsan, A., Beaussier, C., Diwan, J., Sapon-Cousineau, S...
Focus: Spatial multi-omics resolve epithelium-fibroblast gradients and highlight NESTIN-NOTCH1-expressing subepithelial fibroblasts during human pancreatic tumorigenesis.
Intraductal papillary mucinous neoplasms (IPMNs) are cystic precursors of pancreatic ductal adenocarcinoma undergoing dynamic epithelial and stromal remodeling during progression.
In this study, we integrated computational pathology, cyclic immunofluorescence, and Xenium spatial transcriptomics to define the spatial organization of the IPMN microenvironment.
Shaikhutdinova, R., Gansberger, S., Staller, J., Singh, N., Oyarzun, I., Simon, M., Sterniczky, B., Tschandl, P., Griss, J.
Focus: Independent benchmark of H&E-based gene expression prediction in skin.
Given the widespread availability of H&E slides, there is considerable interest in determining whether molecular information can be inferred directly from tissue morphology, potentially reducing the need for…
We assessed three state-of-the-art methods for predicting single-cell gene expression from H&E images across three skin disease contexts and two Xenium.
Focus: EVd3x: A Bioinformatics Platform for Evidence-aware Interpretation of EV Cargo.
Extracellular vesicle (EV) profiling can identify hundreds to thousands of RNAs and proteins, but converting those lists into a coherent biological interpretation remains slow because the relevant evidence…
We introduce EVd3x.com, a source-linked bioinformatics platform that brings thes.
Corre, G., Rouillon, M., Mombled, M., Amendola, M.
Focus: GENETHOFF: a flexible workflow for genome wide profiling of CRISPR/Cas off targets.
We developed GENETHOFF, a flexible single-command versatile Snakemake workflow designed for the comprehensive analysis of CRISPR/Cas9 related OFF-targets genomic positions from GUIDE-Seq derived protocols.
It efficiently processes multiplexed libraries from different organisms, PCR orientations, and Cas nucleases with varying PAM specificities in a single run, all based on a simple user-specified.
Mutti, C. D., Van Haute, L., Luengo-Gutierrez, L., Dowling, I., Barrera-Paez, J. D., Turner, K., Silva-Pinheiro, P., Minczuk, M.
Focus: Mitochondrial adenine base editing of mouse somatic tissues via adeno-associated viral delivery.
The development of adenine base editing in mitochondria, alongside cytidine base editing, has significantly expanded the genome engineering capabilities of the mitochondrial DNA.
We tested the recent advancements in adenine base editing technology using optimised TALEs targeting genes Mt-Cytb, Mt-CoII and Mt-Atp6 in mouse cells, and observed successful A:T to G:C…
Costa, E. J., Rios-Martinez, C., Andrews, C. J., Ferrell, J. E., Bintu, L.
Focus: Stable epigenetic states set single-cell activation thresholds in mammalian expression systems.
Quantitatively relating transcription factor (TF) input to gene expression output is central to understanding mammalian gene regulation and essential for designing predictable synthetic expression systems.
However, even minimal synthetic systems often exhibit unexplained behaviors.
Luffman, N., Hu, B., Koblinski, J., Gewirtz, D., Harada, H.
Focus: Sacituzumab Govitecan as an Effective Strategy for Sensitizing Chemoresistant HNSCC Cells to Senolytic Intervention.
Head and neck squamous cell carcinoma (HNSCC) is the sixth most prevalent cancer worldwide and is marked by a high tumor relapse due to acquired chemoresistance, requiring alternative…
Sacituzumab govitecan (SG), a TROP2-targeting antibody-drug conjugate, has been successful in limiting tumor progression in pretreated patients with triple-negat.
Foster, J. G., Wozniak, E., Mein, C. A., Thompson, J., Stricker, P., Haynes, A.-M., Rajan, P.
Focus: Transcriptome profiling of cell-free RNAs in prostate cancer patients on active surveillance.
Active surveillance (AS) delays or avoids unnecessary treatment-related side effects for early localised non-aggressive prostate cancer (PCa) through monitoring with regular prostate-specific antigen (PSA) testing, digital rectal examination…
Whilst baseline MRI has prognostic value and is increasingly used for disease monitoring, molecul.
Gaucher, C., Kaya, M., Garnier, J., Barthelemy, A., Rochigneux, P., Poizat, F., Rubis, M., Moussard, P., Roques, J., Fraunhoffer, N., Dusetti, N. J., Chanez, B.
Focus: Transcriptomic FOLFIRINOX sensitivity signatures stratify overall survival and reveal directional reclassification after neoadjuvant FOLFIRINOX in borderline resectable and locally advanced pancreatic cancer.
Background: Transcriptomic FOLFIRINOX-component sensitivity signatures have been clinically evaluated in resected and advanced PDAC, but their relevance and longitudinal stability in the neoadjuvant BR/LA setting are unknown.
Patients and methods: We retrospectively studied 77 patients with borderline resectable or locally advanced PDAC treated with neoadjuvant FOLFIRINOX followed by resection.
Bladder cancer develops through multistep molecular alterations, yet the events underlying tumor initiation and progression remain poorly understood.
Here, we reconstructed stepwise bladder carcinogenesis using canine bladder organoids combined with chemical carcinogenesis and serial xenotransplantation.
Guarnaccia, G., Massenet, J., Cecchini, A., Guarnaccia, E., Silvestri, B., Nicoletti, C., Barajas, J. R., Sala, D., Garcia Teneche, M., Li, B., Caputo, L., S...
Focus: Tumor-derived SAA1-TLR4 signaling drives tumor-to-muscle communication in pancreatic cancer cachexia.
Cancer cachexia limits treatment tolerance and survival in pancreatic ductal adenocarcinoma (PDAC), yet the tumor-derived signals driving tissue dysfunction remain poorly understood.
Here, we identify serum amyloid A1 (SAA1) as a mediator of tumor-to-host communication acting through Toll-like receptor 4 (TLR4).
Hernandez-Hernandez, A., Höjer, P., Ljungmark, M., Glaros, A., Choi, E., Hauenstein, J., Frengen, N., Björnerfeldt, S., Enström, C., Mansson, R., Nordlund...
Focus: Comparative analysis of whole genome amplification kits for single-cell genome analysis.
Whole genome amplification (WGA) enables detailed analysis of genomic heterogeneity at the cellular level.
Here, we systematically compare two commercially available WGA technologies on single cells.
Focus: Evaluating Few-Shot Meta-Learning using STUNT for Microbiome-Based Disease Classification.
The human gut microbiome is increasingly explored as a diagnostic indicator for disease, yet machine learning models trained on metagenomic data are often constrained by limited sample sizes…
Meta-learning, a machine learning paradigm that optimizes models for rapid adaptation to new tasks with limited examples, offers a promising strategy to address this by.
Soman, J., Kundu, A., Newington, J., Wong, S., Desai, N., Leung, S., Cudini, J., Suarez, F., Grandsard, P.
Focus: Novel Target Combinations in Lung Squamous Cell Carcinoma proposed by the Emet AI Research Environment and supported by discovery stage experimentation.
Early drug discovery is frequently bottlenecked by target identification, a challenge that becomes particularly difficult in complex diseases driven by overlapping, redundant pathways rather than a single dominant…
Lung squamous cell carcinoma (LUSC) is one such disease: mutationally complex, lacking a dominant actionable target, and marked by a long series of failed single-agent targeted t.
Focus: Revisiting bacterial division control with likelihood inference: limited identifiability of simple models.
Cell-division control in bacteria has been studied for many years, but gaps in understanding its logic still remain.
Simple candidate models of cell division control have been studied, but are assessed with heuristic analysis of single-cell data that does not provide a quantitative scale for comparison.
Guo, T. J. F., Meng, Y., Kim, S., Machiri, T., Miscampbell, A., Lau, K. S. K., Gibbons, C., Penton, M. R., Lee, C. P. S., Li, I. T. S., Goobie, G. C., Halayk...
Focus: Characterization of tri-culture alveolar-like organoids to study fibrotic lung diseases.
Rationale: Fibrotic interstitial lung diseases are progressive disorders characterized by lung scarring and declining respiratory function.
Repeated injury and dysregulated epithelial-mesenchymal crosstalk are implicated in disease pathogenesis but remain incompletely understood.
D'Ariano, G., Zhang, G. J., Cala, G., Carrino, G. M., Agarwal, A., Mariani, A., Marinaro, M., Matias de Sousa, R., Cenedese, G., Camilli, C., David, A. L., E...
Focus: Derivation of primary fetal epithelial organoids from cryopreserved human amniotic fluid cells.
Primary fetal human epithelial organoids are canonically derived from tissue samples obtained after termination of pregnancy.
Recently, we have demonstrated that these organoids can be consistently generated from amniotic fluid cells isolated prenatally during diagnostic and interventional procedures.
Bhaskaran, J., Ing-Simmons, E., Balaguer Balsells, I., Di Persio, S., Chan, M. M., Politz, M., Cremers, J.-F., Rotte, N., Kliesch, S., Friedrich, C., Tuettel...
Focus: A single-nucleus multiomic and spatial atlas of gene regulation in human spermatogenesis.
Gametogenesis, the production of oocytes and sperm, ensures the faithful transmission of genetic material to the next generation.
In males, spermatogenesis occurs within the testis, where germ cells progress through a highly ordered developmental programme in close association with supporting somatic cells.
Focus: SPARKLE: evidence-constrained correction of local RNA leakage in high-resolution spatial transcriptomics.
High-resolution sequencing-based spatial transcriptomics, including Stereo-seq and Visium HD, aggregates dense capture units into cell-resolved expression matrices.
During tissue processing and permeabilization, RNA released from source cells can spread to neighbouring capture locations, reducing cell-type specificity and biasing downstream analyses.
Zhang, L., Rao, H., Li, M., Qian, X., Zhang, Y., Yan, Q., Gao, R.
Focus: AnnoAudit: a marker-based protocol for auditing single-cell atlas annotations reveals annotation-driven artifacts in a widely used traumatic brain injury resource.
Single-cell atlas annotations are routinely treated as ground truth but rarely validated before use.
We present AnnoAudit, a marker-based audit protocol that combines four convergent checks - marker scoring, unsupervised clustering, margin-gated module scoring, and applicability-gated pretrained models - into a composite…
Focus: CellART: a unified framework for extracting single-cell information from high-resolution spatial transcriptomics.
Understanding how different cell types assemble into tissues and organs, as well as how they interact to transmit and receive biological signals, is essential for advancing biomedical and…
Recent advancements in spatial transcriptomics (ST) technologies have opened new avenues for investigating biological systems by achieving subcellular spatial resolution.
Xu, H., Ye, Y., Zhang, S., Xie, R., Li, J., Lin, J., Hu, Y., Gao, L.
Focus: Atlas-scale single-cell analysis beyond in-memory paradigm with scAtlasPy.
Single-cell atlases are rapidly outgrowing the memory capacity of standard workstations, challenging the in-memory paradigm underlying mainstream computational ecosystems.
Here, scAtlasPy decouples scale of atlas from memory capacity by leveraging the disk-resident computing.
Bergeron, D., Gaudreault, V., Duval, M., Nassari, S., Boudreau, F., Durand, M., Choquet, K., Jean, S.
Focus: NANOCUTSIGHT: A NANOPORE-SEQUENCING APPROACH AND ANALYSIS PIPELINE TO ASSESS GENOME EDITING EFFICACY IN VARIOUS CELL POPULATIONS.
Genome editing has revolutionized biomedical sciences and is now an essential tool to define molecular pathways through genetic interaction and loss-of-function studies.
Through its diverse variations, it allows for the generation of specific knockout cell lines or organisms, as well as the creation of endogenously edited gene regions.
Focus: Protein Design Viz (PDV): lightweight protein structure visualization studio with validated quantitative analytics and antibody-specific toolkit.
Motivation: Molecular visualization is dominated by two families of software.
Desktop programs such as PyMOL, VMD and UCSF ChimeraX are powerful but heavy to install and operate.
JournalLife scienceScience (New York, N.Y.)2026-09-08
Nagai S, Yang C, Chen DH, Trnka MJ, Bushnell DA, Burlingame AL, Murakami K, Kornberg RD.
Focus: Structural basis of a SWI/SNF-associated transcription pre-initiation complex.
The mating type switching/sucrose non-fermenting (SWI/SNF) chromatin remodeling complex removes and repositions nucleosomes at promoters for the initiation of transcription.
Though long thought to function independently, we find that SWI/SNF is an integral component of the transcription machinery.
Wu, H., Lister, A., Macaulay, I. C., Long, K., Uauy, C., Lan, Y., Wickham, G. J., Swarbreck, D., Videm, P., Stubbs, A., Soranzo, N., de Waard-van Baardwijk, ...
Focus: EISCA and EISTA: Full-Spectrum Pipelines for Single-Cell and Spatial Transcriptomics Analysis.
Single-cell and spatial transcriptomics are transforming our understanding of cellular heterogeneity and tissue organization, yet their analytical complexity remains a major bottleneck.
Here, we present EISCA and EISTA, two standardized, end-to-end pipelines for single-cell RNA-seq and imaging-based spatial transcriptomics analysis.
Neupane, A., Wollman, J. W., Donahoe, J., Pradhan, B., Balster, J. J., Poudel, S., Waniarachchi, K., Hoppe, A. D., Swanson, J. A., Scott, B. L., Thiex, N. W.
Focus: PI(3)P Signaling by VPS34 Complex II Orchestrates Macropinocytosis.
Macrophage macropinocytosis contributes to wound healing, antigen presentation, and resolution of inflammation.
Macropinocytosis also facilitates nutrient uptake and growth in macrophages, T cells, and cancer cells.
Ngo, W., Rosas-Rivera, D., Wasko, K. M., Qiu, L., Kang, M. H., Gogna, S., Zeng, J., Hooks, M. T., Wu, J. L. Y., Li, Z., Doudna, J. A.
Focus: Amplified genome editing by in vivo editor production.
Genome editing enzymes have vast therapeutic potential.
However, achieving sufficient delivery in vivo remains a major challenge, because editing machinery is confined to the subset of transfectable cells in a tissue.
Hu L, Sun J, Morse KW, Bok S, Zheng Y, Chan UI, Choi H, Macfarlane E, Yallowitz AR, Cung M, Cong T, Carpen PL, La Manna F, Debnath S, Li H, Xu T, Wang L, Zhe...
Focus: Identification of the tendon/ligament stem cell in mice and humans.
Ligamentum flavum (LF) hypertrophy resulting in spinal cord compression is a key cause of lumbar spinal stenosis (LSS).
There are no medical therapies for LSS, in part because the identity of the tendon/ligament stem cell (TLSC) mediating LSS remains unclear.
Buker, I. E., Ni, Y., Hicks, S. C., Kang, J., Acharyya, S.
Focus: SCG: Spatially Co-Expressed Gene Identification through Spatially Varying Networks.
Spatial transcriptomics has enabled the advancement of gene expression analysis, yet spatial co-expression remains understudied.
We introduce spatial covariance regression (SCR), a scalable Bayesian factor-model-based framework for estimation of spatially-resolved gene co-expression networks across tissue domains.
Focus: Covariance Nonstationarity is Evident in Spatial Transcriptomics and Provides a New Categorization of Spatially Varying Genes.
Gaussian process models underlie many spatial transcriptomics tools but typically assume stationary covariance.
Covariance non-stationarity has long been recognized in spatial statistics as an important feature of spatial data, yet it has received little attention in spatial transcriptomics.
Focus: platpy: A spatial-first framework for multi-layer spatial transcriptomic analysis.
Background The emergence of accessible spatial transcriptomic platforms such as 10x Genomics Visium HD and Xenium has created demand for analysis tools that can handle the complexity and…
Current frameworks approach spatial data primarily as an extension of single-cell RNA-seq pipelines, where spatial coordinates are retained as metadata rather than treated as a first-cla.
Mitotic spindle orientation is tightly controlled in epithelia to preserve polarized tissue architecture.
Here, we uncover a previously unrecognized role of the adherens junction protein {beta}-catenin in regulating planar mitotic spindle positioning required for symmetric epithelial cell division.
Yu, M., Xie, Y., Allen, L., Carter, K., Donato, E., Cheng, L., Kendziorski, C., Matkowskyj, K. A., De Marzo, A. M., Hicks, J., Reddi, D., Newell, E. W., Sun,...
Focus: Spatial multi-omics and single-cell transcriptomics uncover senescence-associated cellular programs during colon adenoma to cancer progression.
Colorectal cancer develops through a normal-adenoma-carcinoma sequence, yet only 5-10% of adenomas progress to malignancy, and the cellular programs governing that sequence remain poorly defined.
Here we generate a spatial multi-omics atlas of human colon adenomas, combining Visium CytAssist and protein co-detection across 24 nonadvanced and advanced tubular adenomas with single-cell resolution Xe.
Oksza-Orzechowski, K., Lazecka, M., Koperski, L., Wojtowicz, D., Mozejko, M., Schulz, D., Liechti, R., Marzetta, F., Morfouace, M., Hong, H. S., Tissot, S., ...
Focus: Modelling interpretable patient-level representationsfrom structured and simple multimodal data.
Patient cohort profiling increasingly includes structured views for multiple modalities, such as single-cell RNA sequencing, spatial transcriptomics or proteomics, and histology, each providing multiple subobservations per patient, including…
To model such data along with simple patient-level views, current multimodal integration methods typically rely on sep.
ANILKUMAR REKHA, A., Bettacchioli, E., Le Dantec, C., Hemon, P., Jouve, P. E., Hillion, S.
Focus: AltraFlowSOM: A Semi-Supervised Framework for Imaging Mass Cytometry Phenotyping.
Imaging Mass Cytometry (IMC) enables the simultaneous quantification of 40+ protein markers at single cell resolution in tissue, however biologically faithful phenotyping at scale remains a critical bottleneck.
Unsupervised clustering fragments coherent populations or conversely merges biologically incoherent ones into a single cluster, supervised classifiers impose a closed vocabulary, and the pr.
Focus: Poly Pipeline: A Polyvalent Spatial Transcriptomics Workflow Validated Across Polyploid and Diploid Organisms.
Spatial transcriptomics (ST) has emerged as a transformative approach for visualizing tissue landscapes, yet it faces significant challenges regarding data standardization, sparsity, and the analysis of complex genomes…
To address these limitations, we introduce Poly Pipeline, a robust and universal bioinformatic workflow designed to streamline analysis across divers.
Focus: Integrating Spatially Adjusted Protein Summaries for Survival Prediction in Spatial Proteomics.
Recent advances in spatial proteomics, particularly imaging mass cytometry, enable the measurement of protein expression at the single-cell level while preserving a spatial context.
Conventional survival analyses, however, typically rely on patient-level averages of protein intensities and therefore overlook spatial heterogeneity and tissue architecture.
Lian S, Wang W, Liu Y, Lu M, Han W, Luo J, Zhang X, Pang Y, Li Y, Li Y, Dang X, Wang P, Qin Y, Tan N, Zhang F, Zhang J, Gao S, Zhang R, Guo L, Jiang L, Zhang...
Focus: Spatially resolved single-cell atlas reveals the macroevolutionary trajectory of animal hearts.
Animal hearts display diverse anatomical structures during adaptive evolution.
Here, we present a multiomics atlas of adult hearts from 27 species across chordates, arthropods, and mollusks.
Heles M, Pasvolsky L, Sathishkumar H, Naara S, Vu Y, Stewart CL, Xie T, Gleber-Netto FO, McCarthy W, Yaniv D, Kamal SS, Elahi H, Zhu P, Uhelski ML, Chatwin J...
Focus: Psilocybin prevents chemotherapy-induced peripheral neuropathy through mitochondrial trafficking preservation.
Chemotherapy-induced peripheral neuropathy (CIPN) is a disabling, often irreversible toxicity that affects millions of patients, limits life-saving cancer therapy, and lacks proven treatment.
In this work, we show that as little as two doses of psilocybin before chemotherapy durably prevented the onset of CIPN across platinum- and taxane-based models, including repeated…
Nguyen CV, Martija A, Jaklic DC, White R, Yang MG, Nano PR, Soto JA, Mil J, Rana D, Martin JM, Schweiger HE, Hernandez S, Fazzari E, Liu Y, Parent JM, Mostaj...
Focus: Thalamic NRXN1-mediated input to human cortical progenitors drives excitatory neurogenesis.
The human cerebral cortex develops through coordinated signals from within the cortex and from other brain regions, including the thalamus.
However, how thalamic neuronal projections influence early human cortical development remains less well-understood.
Wesolowski AJ, Pillay AM, Vardaka P, Nasrallah R, Greaves R, Li H, Loffreda I, Jenkin C, James AM, Nübling A, Ward CJ, von Linde T, Conti AG, Tzeng SF, Dahma...
Focus: Tumor-derived antioxidants suppress immunity by depriving T cells of reactive oxygen species.
Reactive oxygen species (ROS) promote genomic instability and fuel oncogenic signaling in cancer, but antioxidant therapies have so far failed to improve, or worsen, cancer outcomes.
Emerging data suggest that T cells depend on ROS for signal transduction.
JournalLife scienceScience (New York, N.Y.)2026-09-03
BESIII Collaboration†, Ablikim M, Achasov MN, Adlarson P, Ai XC, Aliberti R, Amoroso A, An Q, Bai Y, Bakina O, Ban Y, Bao HR, Bao SS, Batozskaya V, Begzsuren...
Focus: Measurement of the Λ electric dipole moment with an entangled baryon-antibaryon system.
The dominance of matter over antimatter in the Universe has consistently driven the pursuit of new physics beyond the Standard Model that violates charge-parity symmetry.
Strange baryons (hyperons) remain a largely unexplored territory in which interactions between hyperons and particles from new physics could induce a nontrivial electric dipole moment (EDM).
JournalLife scienceScience (New York, N.Y.)2026-09-03
El-Sayed Moustafa JS, Ramisch A, Raza YN, Leday GGR, Jiao Y, Wang D, Stevens M, Roberts AL, Tomlinson M, Yan X, Ing-Simmons E, Wadge S, Abdalla M, Falchi M, ...
Focus: Longitudinal dynamics of gene expression and metabolomics in an aging population cohort.
Multiomic profiling provides a comprehensive physiological overview at the molecular level, but understanding of its spatiotemporal dynamics remains limited in human populations.
We profiled longitudinal whole-blood gene expression and metabolite levels in 335 females over 8 years.
JournalLife scienceScience (New York, N.Y.)2026-09-03
Lavine MS, Smith KT, Sonawala U, Seale M, Nusinovich Y, Szuromi P, Hullman J, Scanlon ST, Lopez B, Jiang D, Simonti C, Ross SH, Maroso M, Stajic J, Kelly PN,...
Focus: In Science Journals.
Highlights from the.
Science family of journals.
JournalLife scienceScience (New York, N.Y.)2026-09-03
Corsi F, Steinacker TL, Kolesnikova S, Takács Z, Batty P, Mitter M, Gerlich DW, Goloborodko A.
Focus: Conformational asymmetry of replicated human chromosomes.
DNA replication generates sister chromatids with identical sequence, yet its mechanism is fundamentally asymmetric: Chromatids inherit strands of opposite orientation, whereas forks synthesize new strands by distinct leading-…
How this replication asymmetry affects chromosome organization is unknown.
JournalLife scienceScience (New York, N.Y.)2026-09-03
Focus: (Un)intended consequences of mass-prescribing GLP-1s.
It is difficult to overstate how much glucagon-like peptide-1 (GLP-1) pharmacotherapies have inundated the public discourse on obesity.
An avalanche of scientific papers, news articles, and social media posts debate the efficacy, affordability, and appropriateness of GLP-1 receptor agonists not just for obesity but also skin…
JournalLife scienceScience (New York, N.Y.)2026-09-03
Kenny EM, Dharmavaram A, Lee SU, Phan-Minh T, Rajesh S, Hu Y, Major L, Tomov MS, Shah JA.
Focus: Explainable deep learning improves human mental models of self-driving cars.
Self-driving cars increasingly rely on deep neural networks to achieve human-like driving 1-3.
The opacity of these black-box planners makes it challenging to accurately anticipate when they will fail 4-6 , with potentially catastrophic consequences 7-9.
Gallage S, Govaere O, Anstee QM, Shulman GI, Tacke F, Heikenwalder M.
Focus: Current therapeutic landscape and future treatment perspectives of MASH.
Metabolic dysfunction-associated steatohepatitis (MASH), the progressive form of metabolic dysfunction-associated steatotic liver disease (MASLD), is a heterogeneous and systemic disease that confers risk not only for cirrhosis and…
Klimesch J, Arlt S, Ruiz-Gonzalez C, Rodríguez C, Gu X, Haslinger P, Vischia P, Haack C, Drori Y, Adhikari R, Arndt M, Kagan M, Heinrich L, Krenn M.
Focus: Designing physics experiments with artificial intelligence.
Progress in physics has long been driven by ingenious experiments conceived by human experts.
Recently, design methods driven by artificial intelligence (AI) have begun to move beyond tuning a handful of parameters to proposing entirely new experimental layouts.
Gallage S, Govaere O, Anstee QM, Shulman GI, Tacke F, Heikenwalder M.
Focus: Molecular mechanisms and pathogenesis of MASH.
Metabolic dysfunction-associated steatotic liver disease (MASLD), including its progressive form metabolic dysfunction-associated steatohepatitis (MASH), represents the hepatic manifestation of metabolic syndrome and is increasingly recognized as a multi-organ…
MASLD is now the most prevalent chronic liver disease worldwide and a rising indication for liver transplantation.
Venezia O, Kane H, Du G, Coughlan HD, Johanson TM, Wang H, Tilstam P, Kazer SW, Gunner G, Hoagland DA, Basavappa MG, Ravichandran K, Ada E, Zhakyp A, Kumar S...
Focus: Functional chimeric mRNAs encode proteins in mammalian immunity.
Individual mammalian mRNAs and proteins are typically believed to originate from single genomic loci, with isoform diversity arising through cis-splicing of pre-mRNA.
Whether mRNA from distant genes can undergo trans-splicing to generate functionally relevant chimeric transcripts has remained unclear.
Schwaba T, Clapp Sullivan ML, Akingbuwa WA, Ilves K, Tanksley PT, Williams CM, Dragostinov Y, Mallard TT, Tubbs JD, Liao W, Ackerman LS, Fealy JCM, Hemani G,...
Focus: Robust inference and correlates from genetic associations with personality.
Personality traits describe stable differences in how people think, feel and behave, and how they interact with and experience their social and physical environments 1,2.
Many questions remain unanswered about associations between DNA and personality traits, such as their robustness, their generalizability and the biological and social pathways through which they act.
Focus: The nutritional value of invertebrate aquatic foods.
Most of the global population has inadequate micronutrient intake 1 , leading to cascading adverse effects on economies and human health 2.
Aquatic invertebrates are a diverse, productive and socioecologically important food 3,4 , yet their contribution to human nutrition is frequently overlooked 5.
Mayer C, Woo MS, Sonner JK, Binkle-Ladisch L, Fischbach F, Sekol P, Smith MD, Lucas-Ruiz F, Manteufel D, Mattern KM, Pfeffer LK, Guo Y, Siebels B, Miguela A,...
Focus: Intracellular complement factor H protects neurons during CNS inflammation.
Neurodegeneration is a major driver of disability in multiple sclerosis (MS), the most common chronic inflammatory disease of the central nervous system (CNS) 1.
Retinal ganglion cells (RGCs), a heterogeneous neuronal population in the eye, undergo degeneration in MS and provide a model to study neuronal subtype-specific resilience to inflammatory injury 2…
Jones IR, Wang L, Kosicki M, Battle SL, Narayan VJ, Bi Q, Gemenes K, Liu Y, Zhou L, Song M, White M, Olson W, Beuchat G, Dickel D, Li Y, Pennacchio LA, Hawki...
Focus: 3D epigenome of glial cell types in developing human cortex.
The human cortex is complex and heterogeneous, undergoing extensive expansion during development 1,2.
Our prior study of neurogenesis, including radial glia (RG), intermediate progenitor cells, excitatory neurons and interneurons demonstrated that chromatin looping underlies transcriptional regulation for lineage-specific genes, shedding light…
Feng Y, Barthez M, Wang Y, Chen Y, Qiu H, Wang CL, Heydari K, Delcroix M, Rasmussen LJ, Bohr VA, Chen D.
Focus: Late-life semaglutide treatment slows ageing and extends lifespan in female mice.
Pharmacological glucagon-like peptide-1 receptor (GLP-1R) activation reduces food intake and is an effective therapy for type 2 diabetes and obesity 1.
The use of GLP-1 medicines has revealed pleiotropic beneficial effects beyond glucose and weight control 2-5 , but little is known about the underlying basis of the pleiotropic…
Li XY, Cai YC, Meng ZD, Jia ZT, Sun YC, Ye JY, Tian N, Zhou ZY, Huang J, Chen J, Sun SG, Wang T.
Focus: Probing far-from-equilibrium dynamics of electrical double layers.
Electrified solid-liquid interfaces are central to energy and matter conversion in biological 1 and electrochemical systems 2-4 , in which intense local electric fields govern reaction kinetics 5-9…
Yet, under realistic electrocatalytic conditions involving rapid charge transfer and far-from-equilibrium dynamics, the molecular structure and evolution of the electrical.
Perks KE, Petkova MD, Muller SZ, Genecin M, Ghatare A, Schalek R, Wu Y, Januszewski M, Jain V, Lichtman JW, Abbott LF, Sawtell NB.
Focus: Connectome analysis of a cerebellum-like circuit for sensory prediction.
Many forms of learning, for example, learning a model of the environment or a motor skill, rely on synaptic plasticity that is widely distributed across cell types and…
Understanding how this distributed plasticity functions is a central challenge in neuroscience 1-5.
Alizadeh K, Klepacki D, Vázquez-Laslop N, Mankin AS.
Focus: Rewiring the ribosome to translate proteins encoded in its own RNA.
Cellular protein synthesis relies on random encounters between ribosomes and mRNAs, limiting optimization of the translation machinery for production of a single protein-a key need in biotechnology.
One potential solution is integrating the protein-coding sequence into the ribosome itself, thereby committing the ribosome to synthesis of a single polypeptide.
Linville RM, James BT, Galani K, Ho LL, Shin JH, Oliver E, Fass SB, Cameron JC, Fitzwalter BE, Bock R, Murray EM, Louçã M, Oke O, Wang C, Engelberg-Cook E, D...
Focus: Cross-species single-cell atlas of the striatum defines cell-type and subregion disease vulnerabilities.
The striatum is critical for decision-making, movement, and reward processing, functions achieved through subregional cellular and molecular specialization.
Striatal cell types and subregions are differentially implicated in neurodegenerative and neuropsychiatric disorders, but the mechanisms underlying these vulnerabilities are poorly understood.
Focus: The regulatory logic linking inflammation and fibrosis.
Whether tissue injury resolves or progresses to chronic scarring is determined by regulatory choices that remain only partially understood.
In this review, we propose that immune cells and fibroblasts function as dynamic interpreters of intercellular cues, integrating these signals through chromatin-regulated gene circuits that govern cell state…
Peripheral serotonergic signaling has been implicated in diverse physiological processes, yet its role in coordinating glial-immune interactions remains poorly understood.
In this issue of Cell, Wen and colleagues identify enteric glial cells as critical effectors of peripheral 5-HT2AR agonism, uncovering a serotonergic neuroimmune circuit that drives cytotoxic T…
Shi H, Bennett EA, Chen G, Wang H, Wang T, Cao P, Mao R, Bai F, Dai Q, Liu F, Feng X, Wang Y, Yao C, Wu J, Wang W, Zhang M, Liu T, Ran J, Liu YC, Liu Y, Ju D...
Focus: Genomics and social practices at Mogou and other Gansu sites during prehistoric trans-Eurasian exchange.
Beginning approximately 4,000 years ago, southwest-Asian-originating domesticated crops and livestock began appearing in Gansu, a key crossroads in northwestern China, yet the population dynamics and social practices underlying…
Despite the adoption of western domesticates, genome sequences of 149 individuals from.
Hoeller J, Zhao A, Nern A, Rogers EM, Romani S, Reiser MB.
Focus: The organization of visual pathways in the Drosophila brain.
Visual systems transform photoreceptor inputs into rich perceptual representations through hierarchical networks that extract features along parallel pathways.
Although this architecture is conserved across species, how visual information is routed throughout an entire brain remains elusive in any animal.
Tastekin I, de Haan Vicente I, Beresford RJ, Morris BJ, Beckett I, Schlegel P, Gkantia M, FlyEM Project Team, Cambridge Connectomics Group, Marin EC, Costa M...
Focus: The complete gustatory connectome of adult Drosophila reveals how taste guides feeding, foraging, and social behavior.
Gustatory systems drive critical survival behaviors such as feeding, foraging, and social interactions.
However, gustation remains one of the least mapped sensory modalities at the connectome level.
Berg S, Beckett IR, Costa M, Schlegel P, Januszewski M, Marin EC, Nern A, Preibisch S, Qiu W, Takemura SY, Fragniere AMC, Champion AS, Adjavon DY, Cook M, Gk...
Focus: Sexual dimorphism in the complete Drosophila male central nervous system connectome.
Sex differences in behavior exist across all animals, typically under strong genetic regulation.
In Drosophila, fruitless/doublesex transcription factors identify dimorphic neurons, but their organization into functional circuits remains unclear.
Focus: Metabolite buffering of labile iron governs ferroptosis.
Iron abundance alone does not determine ferroptosis sensitivity.
In this issue of Cell, Sharma and colleagues identify polyamines as endogenous metabolic buffers that reduce the chemical accessibility of labile iron, revealing an unexpected function for one…
Najia MA, Le A, Borrajo J, Pruett L, Tsai F, Ogi R, Huang JY, Griffith LG, Daley GQ, Blainey PC.
Focus: Live-cell transcriptomics with engineered virus-like particles.
Transcriptomic profiling is widely applied to characterize cellular gene expression, yet existing approaches lyse cells and preclude direct analysis of transcriptional dynamics in the same sample over time.
We addressed this limitation by engineering mammalian cells to "self-report" their transcriptional states via mRNA export in virus-like particles (VLPs).
Focus: Oxygen-responsive bacterial glycosphingolipid links symbiont fitness and immune development in neonatal host.
Symbiotic gut bacteria must re-establish themselves in every host generation, yet the molecular strategies enabling this inheritance remain poorly understood.
Here, we show that Bacteroides fragilis uses a membrane glycolipid, alpha-galactosylceramide (BfaGC), to colonize the neonatal gut.
Gray MA, Randal KL, Co JA, Tang MT, Xue AZ, Chen SW, Razumkov H, Omran QQ, Solow-Cordero DE, Yu J, Robinson SA, Starnbach CA, Gray NS, Corsello SM, Banik SM.
Focus: Ratiometric transcriptional activation by protein degradation.
Cells can respond to alterations in the abundances of specific proteins through transcriptional outputs.
Synthetic approaches inspired by native post-transcriptional circuits that convert protein abundance changes into programmable gene expression would be transformative.
Chen Y, Yserentant K, Hong K, Chen K, Kuang Y, Picardo RS, Bhowmick A, Charles-Orszag A, Lord SJ, Lu L, Hou K, Mann SI, Bhattacharya S, Horst M, Grimm JB, La...
Focus: De novo pan-rhodamine binders for fluorescence microscopy from mammalian cells to extremophiles.
Fluorescent imaging in live cells is a cornerstone of life sciences.
While natural fluorescent proteins have been engineered to enhance individual features, no existing tag combines ideal properties into a single system: high brightness, reversible binding, compact size, and…
Adduri AK, Gautam D, Bevilacqua B, Naghipourfar M, Imran A, Shah R, Teyssier N, Verma R, Carpenter C, Eraslan B, Chalissery F, Ilango R, Subramanyam V, Ricci...
Focus: Predicting cellular responses to perturbation across diverse contexts with State.
While machine learning models offer potential for predicting transcriptomic effects of perturbation, they currently struggle to generalize across cellular contexts.
Here, we introduce State, a machine learning model that predicts perturbation effects while accounting for cellular heterogeneity within and across experiments.
Gowrishankar R, Hjort MM, Elerding AJ, Shirley SE, Senthilkumar P, Van Tilburg J, Marcus DJ, Abrera KA, Sumarli D, Wezik M, Motovilov K, Gordon-Fennell AA, Z...
Focus: Endogenous opioid dynamics in the dorsal striatum sculpt neural activity to promote goal-directed action.
Endogenous neuropeptides are uniquely poised to regulate neuronal activity and behavior across multiple timescales.
Traditional studies ascribing neuropeptide contributions to behavior lack spatiotemporal precision.
Zhu R, Dann E, Yan J, Reyes Retana J, Goto R, Guitche RC, Brixi L, Ota M, Hartman A, Roth TL, Satpathy AT, Pritchard JK, Marson A.
Focus: Genome-scale perturb-seq in primary human CD4+ T cells maps context-specific regulators of T cell programs and human immune traits.
Gene regulatory networks encode the fundamental logic of cellular functions, but systematic network mapping remains challenging, especially in cell states relevant to human biology and disease.
Here, we perturbed all expressed genes across 22 million primary human CD4 + T cells from four donors and developed a probe-based perturb-seq platform to measure the transcriptome…
Kundnani DL, Lee Y, Yang T, Warner TP, Martinez-Figueroa F, Channagiri T, Xu P, Eckerty RA, Sun M, Randhawa S, Jeon Y, Marsili S, Newnam G, Lu Y, Yasumuro M,...
Focus: Human nuclear ribomes reveal DNA-embedded ribonucleotides as epigenetic modulators of transcription-associated DNA supercoiling.
Ribonucleoside monophosphates (rNMPs) are the most abundant non-canonical nucleotides in DNA, yet their distribution and function in the human nuclear genome remain unclear.
We present high-resolution maps of ∼1 million rNMPs per genome across diverse human cells, revealing a non-random nuclear "ribome," the genome-wide landscape of embedded rNMPs, enriched in GC-rich…
Townley J, Kladwang W, Baker D, Blair HM, Choe CA, El Nesr G, Favor A, Fisker E, Haack DB, He S, Hingey J, Huang PS, Huang R, Joshi CK, Karagianes T, Kubaney...
Focus: De novo design of RNA pseudoknots with deep learning.
RNA design has been hindered by the limited accuracy of three-dimensional (3D) structure prediction.
In this study, we show that intricate RNA structures can be generated with current deep learning tools through accurate de novo design of pseudoknot secondary structures.
JournalLife scienceScience (New York, N.Y.)2026-08-27
Zhou Y, Jin J, Jiang C, Dudchenko O, Pinto BJ, Colaric Z, Khan R, Omer AD, Li X, Song Z, Han L, Chen W, Jiang L, Song Z, Weisz D, Xia Y, Qi Y, Cao Z, Peng Y,...
Focus: Genomic predisposition is associated with the direction of sex chromosome evolution.
Sex chromosome evolution is among the most dynamic genomic innovations in vertebrates, yet why some lineages evolve XY while others evolve ZW remains unclear.
Using chromosome-level genomes from 19 geckos, we found that gecko sex chromosomes originated independently from 16 ancestral chromosomes.
JournalLife scienceScience (New York, N.Y.)2026-08-27