A daily-updated life-science feed prioritizing spatial multi-omics and spatial biology, with synthetic biology, cancer, AI-driven biology, immunology, organoids, organ-on-a-chip, and host–pathogen research — pulled automatically from Nature, Cell, Science, Cancer Discovery, bioRxiv, and arXiv.
140 papers from the last 14 days · last updated 20 Sep 2026, 14:38 UTC
Focus: Developmental xenocortication using human-derived organoids in mice.
The inaccessibility of human brain tissue limits the study of human development and function, a challenge that human stem-cell-derived neural models are beginning to address1,2.
Transplantation of neural organoids into rodent hosts enables the in vivo study of aspects of human neurodevelopment and circuit function, alongside behavioural phenotyping of the host animals.
Science (New York, N.Y.) · 2026-09-10
· 4 media mentions
Focus: Lean adipocyte oxylipin signaling restrains breast cancer through ferroptosis.
Obesity increases breast cancer risk and tumor aggressiveness, yet the mechanisms underlying this association remain unclear.
In this work, we identify a tumor-suppressive lipid signaling pathway in which mammary adipocytes secrete the oxylipin 9S-hydroxyoctadecadienoic acid (9S-HODE).
Focus: Targeted genomic integration and rearrangement using prime assembly.
Although therapeutic genome editing holds great potential to remedy diverse inherited and acquired disorders, targeted installation of medium-to-large genomic modifications in therapeutically relevant cells remains challenging1.
Here we develop prime assembly, an approach that permits DNA sequence assembly and integration in human cells leveraging CRISPR-targeted dual flap synthesis.
Focus: Cohesin reshapes replication fork contacts to aid fork slowing and reversal.
DNA replication forks can be challenged by cancer chemotherapeutic treatments, leading to accumulation of single-stranded DNA and slowdown of DNA synthesis.
The marked plasticity of replication forks under replication stress ensures fork stability, damage tolerance and complete genome duplication1.
Focus: Gliomas phenocopy an inborn error of metabolism to drive neuronal activity and tumor growth.
The metabolic hallmarks of high-grade glioma (HGG) are not fully understood.
Human brain tissue metabolomics revealed that the creatine synthesis pathway intermediate guanidinoacetate (GAA) accumulated ∼100-fold in HGGs relative to controls, which was caused by imbalanced activities of enzymes…
Focus: Norway spruce spatiotemporal programs of conifer reproductive development.
Conifers are essential components of forest ecosystems.
however, their reproductive development remains largely understudied due to their genomes' complexity.
Updated daily from published papers in the feed; preprints are excluded. Candidates come from the last 15 days and are ranked using recent Google News coverage plus 7-day public Bluesky activity and citation growth reported by Europe PMC, with spatial biology prioritized. X and LinkedIn are not counted because reliable public paper-level data are unavailable. Attention indicates current interest, not research quality.
Focus: Human-specific retrotransposons encode the regulatory logic of two lineages in a bipotent neural crest and central nervous system precursor.
Transposable elements are sources of cis-regulatory innovation, and the youngest families are particularly interesting because only recent insertions can account for species-specific regulatory divergence.
SVAs (subfamilies -E, F), LTR5Hs and L1HS are human-specific retroelements.
Noroviruses are a leading cause of gastroenteritis worldwide, yet host factors that restrict norovirus replication are not well understood.
By mining both CRISPR activation and CRISPR knockout genome-wide screens, we identified the interferon-stimulated gene Plscr1 as a restriction factor for murine norovirus (MNV).
Eskow, N. M., Prutisto-Chang, K., Gomez-Munoz, M. A., Kang, M., Illa Bochaca, I., Ibrahim, M., Shadaloey, S. A. A., Flores Yanke, A., Geraldo, L. H., Barisan...
Focus: Cross-species spatial profiling links progranulin to an immune suppressive niche in brain metastasis.
Immune checkpoint inhibitors (ICI) have revolutionized the treatment of brain metastasis (BM), demonstrating intracranial response rates and durability not previously seen with other therapies.
However, approximately 50% of patients do not respond to ICI, and the brain-specific interactions that shape anti-tumor immunity remain poorly understood.
Crampton, C., Fawad, S., Clark, T., Dash, H., Köver, B., Cotton, G., Lee, D., Duff, E., Bottolo, L., Matthews, P. M., Skene, N.
Focus: Single-Cell Study Designs Are Systematically Underpowered for Small-Effect Genes.
Single cell differential expression analysis enables biologists to make statistical conclusions about which genes are up or downregulated in a particular cell type, between two conditions, such as…
However, due to biological and technical noise, these differences are hard to detect reliably.
Newhart, V., Gao, A., Edens, A., Flory, M., Bravo, P., Alam, A.
Focus: Single-cell profiling reveals disruption of cell-cycle homeostasis following JDP2 depletion in colorectal epithelial cells.
Intestinal epithelial cells (IECs) undergo rapid and continuous renewal to maintain gut epithelial homeostasis and barrier integrity at the interface with luminal microbiota, dietary antigens, and enteric pathogens.
IEC proliferation is tightly regulated by a complex machinery of cell cycle regulators and effectors, and genetic or transcriptional dysregulation of cell-cycle regulatory pathways is.
Vragel, G., Nelson-Reid, G., Kostelecky, R. E., Spear, E., Lee, M., Abbott, D. W., van Dyk, L. F., Clambey, E.
Focus: HIGH DOSE GAMMAHERPESVIRUS INFECTION IN MACROPHAGES RESULTS IN INFLAMMATORY MULTIMODAL CELL DEATH.
Human gammaherpesviruses (gHVs) including Epstein-Barr Virus and Kaposis sarcoma associated herpesvirus are linked to cancer and inflammatory disease development.
The outcome of gHV infection is highly regulated by cell type, with macrophages identified as an important early infection target that can also serve as a latency reservoir.
Focus: Multi-model biological and sequence information fusion for gene regulatory network inference from single-cell transcriptomics.
Identification of transcription factor target gene interactions and construction of the gene regulatory networks (GRNs) are essential for understanding the molecular mechanisms underlying transcriptional gene regulation.
Large scale single cell transcriptomics across different tissues offers unprecedented resolution of cellular diversity and regulatory dynamics by capturing gene expression heterog.
Focus: Somatic haplotype reconstruction and variant recalibration from tumor-only long-read sequencing.
Separating somatic from germline variants and reconstructing somatic haplotypes are the two central problems of tumor-only cancer genome analysis.
Long reads carry the linkage needed to solve both, but chromosome-scale loss of heterozygosity (LOH) and an unknown degree of normal-cell admixture blur the distinction between somatic and…
Pruitt, A., Yang, L., Lee, S., Balafkan, N., Gao, S., Seah, C., Dai, Y., Davidson, E., Khan, S., Sen, A., Liu, J., Wood, I., Xu, G., Huang, X., Carlson, M., ...
Focus: Convergent and divergent phenotypic impacts of estradiol on neurodevelopmental disorder risk genes.
Sex hormone signaling during neurodevelopment may act as a modulator of risk for neurodevelopmental disorders (NDDs), including autism spectrum disorders (ASDs).
By conducting a systematic and multi-modal evaluation of estradiol effects across loss-of-function deletions in 36 functionally diverse, large-effect ASD/NDD genes in human induced pluripotent stem cell-derived neurons and…
Goubert, C., Gray, A., Hubley, R., Wheeler, T. J., Smit, A. F. A.
Focus: Updated Transposable Element Libraries for Drosophila melanogaster in Dfam 4.0.
Drosophila melanogaster repeatome, comprising roughly 20% of the genome, is characterized by a large fraction of active TE families counterbalanced by efficient purifying selection.
Consequently, many TE families persist at low copy numbers and are frequently population specific.
Dhoparee-Doomah, I., Li, Y., Al Dow, M., Hajhashemi, S., Brassard, A., Benizri, N., Leo, S., Milne, K., Xu, M. Z., Qiu, Q., Nelson, B. H., Fiset, P.-O., Gian...
Focus: A Measurable Systemic Immune Phenotype Links Circulating Myeloid Dysfunction to Tumour Spatial Organization in Gastroesophageal Adenocarcinoma.
Background: Both static and longitudinal measures of circulating neutrophil-to-lymphocyte ratio (cNLR) are prognostic markers across solid malignancies, including gastroesophageal adenocarcinoma (GEA).
Despite this consistency, cNLR remains poorly integrated into clinical decision-making and is generally regarded as a nonspecific inflammatory or disease-burden signal rather than a defined biologic.
Liu, Z., Song, X., Chen, W.-S., Dhingra, S., He, J., He, L., Chen, C., Balasi, J. A., Sayegh, Z., Moran Segura, C. M., Lopez-Blanco, N., Alleyne, A., Nguyen,...
Focus: Spatially resolved multimodal hallmarks of response to neoadjuvant immunotherapies in the melanoma ecosystem in 2D and 3D.
Neoadjuvant immunotherapy has transformed cancer treatment, yet the spatial molecular architecture governing response and resistance across distinct immune checkpoint blockade (ICB) regimens remains poorly defined.
We assembled the largest neoadjuvant ICB (NICB) spatial multi-omics cohort to date, profiling over 112 million cells at single-cell resolution across three melanoma ICB regimens using M.
Zheng, J., Shi, Y., Sun, Y., Wang, Y., Li, R., Wang, P., Chang, S., Pan, L., Tan, H., Yue, T., Qu, K., Zheng, X., Guo, C., Weng, J.
Focus: A lifespan-scale single-cell atlas defines an early-childhood immunometabolic transition linked to age-referenced immune states.
Childhood represents a critical period with rapid metabolic and immune remodeling, during which perturbations may have lasting consequences for health.
We integrated single-cell RNA sequencing (scRNA-seq) profiles of peripheral blood mononuclear cells (PBMCs) from 2,008 healthy individuals aged 0-100 years.
Honcharuk, V., Takemoto, K., Masalunga, M. C., Zhao, H., Diez, D., Kawaoka, S., Vandenbon, A.
Focus: DeepSpaceDB 2.0: an interactive spatial transcriptomics database for large-scale Xenium data exploration.
The 10x Genomics Xenium platform enables high-resolution spatial transcriptomics at single-cell and subcellular scales, but effective reuse of public Xenium datasets is hindered by large data sizes and…
We previously developed DeepSpaceDB, a spatial transcriptomics database designed for interactive, in-depth analysis of tissues and tissue microenvironments.
Focus: Pretrained gene representations transfer mean expression more broadly than spatial patterns in virtual spatial transcriptomics.
Models that combine tissue images with pretrained gene representations aim to predict spatial expression for genes not used to fit the downstream predictor.
Yet success on held-out genes can reflect two capabilities: estimating a gene's mean expression across tissue locations and recovering its spatial variation.
Hu, E., Gorman Durben, K., Budnik, B., H. Arlow, D., F. Oh, S., Nyerges, A.
Focus: Firewalled synthetic commensal blocks horizontal gene transfer in the gut.
Synthetic biology enables the rational reprogramming of microorganisms into living therapeutics and agents for bioremediation.
However, such genetically modified organisms (GMOs) disseminate their synthetic genetic information into natural microbial communities through horizontal gene transfer (HGT), posing biosafety risks that limit clinical and environmental…
Du, P., Kohno, S., Wang, M., Papanicolaou, M., Vaughan-Jackson, A., Daigh, L., Peng, Q., Spees, K., McCormick, A., Diehl, M., Bintu, L., Qiu, X., Satpathy, A...
Focus: In vivo intercellular CRISPR screens using viral proximity barcoding reveal regulators of tumor-immune interactions.
Cell-cell interactions shape tumor growth, immune evasion, and therapeutic response, but systematically dissecting their genetic regulators in vivo remains challenging.
Existing cell-cell interaction tracing technologies rely largely on protein labels or enzymatic reactions, limiting their information content and scalability.
Sears, T. J., Lee, K.-h., Munoz Perez, M., Rasmussen, R., Pagadala, M. S., Tanaka, K., Subramanian, A., Moding, E. J., Zanetti, M., Carter, H.
Focus: Predicting Neoantigen Immunogenicity from In Vivo Immune Editing.
Neoantigen immunogenicity prediction is fundamental to personalized cancer vaccines, tumor-infiltrating lymphocyte (TIL) therapy, and TCR-T cell engineering.
Existing computational predictors rely primarily on in-vitro correlates of peptide presentation or models trained against assay-based reactivity, and they are typically validated within a single therapeutic setting.
Didi, K., Reidenbach, D., Penner, M., Ravichandran, S., Case, M., Nichols, M., Swanson, E., Reis, A., Prescott, M., Qian, Y., Qian, D., Yang, J., Li, W., Li,...
Focus: Latent generative search unlocks de novo design of untapped biomolecular interactions at scale.
De novo protein design has advanced rapidly, yet designing binders to polar, solvent-exposed epitopes and small, flexible ligands remains challenging.
Such hydrated surfaces and flexible molecules, including carbohydrates, provide few of the hydrophobic contacts favoured by current methods and have largely resisted de novo binders.
Gendron, W. A. C., Smidler, A. L., Li, M., Wise, T., Sanchez C., H. M., Bennett, J. B., Raban, R., Marshall, J. M., Akbari, O. S.
Focus: Split suppression gene drives reveal a design tradeoff between inheritance and reproductive load in Aedes aegypti.
Mosquito-borne pathogens cause approximately 700,000 deaths annually, highlighting the need for effective and sustainable vector control strategies.
CRISPR-based gene drives offer a potential approach for suppressing disease-vector populations, but autonomous drives may spread beyond intended populations.
Focus: Metabolic-Epigenetic Coupling in Cellular Senescence: In Silico Cristae Remodeling Depletes Alpha-Ketoglutarate to Drive KDM4/6 Inhibition and SASP Amplification.
Cellular senescence is governed by complex organellar cross-talk, epigenetic remodeling, and non-canonical signaling cascades that drive chronic tissue degeneration.
In this work, we formulate a predictive computational systems biology framework to investigate these dynamics.
Yuan, L., Li, X., Le, M., Hicks, S. C., Deshpande, A., Taube, J. M., Szalay, A. S.
Focus: Interpretable spherical geometry of single-cell state transitions from dominant principal components.
Single-cell RNA-seq atlases are commonly explored with nonlinear embeddings that preserve neighborhoods but provide limited coordinate-level interpretation.
We asked whether projecting the dominant principal components (PCs) of single-cell gene expression onto a unit sphere would yield an interpretable coordinate system.
Focus: Oligodendrocytes in central nervous system health and disease.
Oligodendrocytes are a specialized class of glial cells responsible for myelination, which sustains central nervous system (CNS) function.
Though long considered a passive and static cell, the oligodendrocyte is now recognized to actively support axonal energy demands through metabolic provision, modify neural signaling in response to…
Wang M, Liu T, Dai Q, Teng J, Wu Y, Jia J, Meng J, Ma Y, Shi H, Cheng X, Liu H, Su Y, Ye J, Chi H, Zhou Z, Sun Y, Wu Y, Chen J, Yin W, Gao P, Song W, Lin R, ...
Focus: mRNA-encoding CD19-targeting T cell engager for refractory immune thrombocytopenia.
While T cell engagers (TCEs) and chimeric antigen receptor (CAR)-T cell therapy show clinical promise for B cell depletion, challenges regarding safety, efficacy, and durability persist.
ABO2203 is a lipid nanoparticle-formulated messenger RNA (mRNA) encoding a CD19-targeting TCE.
Bursic, V., Luo, H., Henon, C., Mao, L., Ehlers, A. C., Yershova, A., Lego, J.-A. M., Li, J., Carreno Gonzalez, M. J., Arndt, R., Sastre, A., Alonso, J., Dir...
Focus: Functional spatial transcriptomics uncover LMO7 as a fusion-regulated and clinically relevant driver of metastasis in Ewing sarcoma.
Metastatic dissemination represents the major determinant of poor clinical outcome across cancer entities.
Yet, how driver oncogenes shape transcriptional programs facilitating metastasis is poorly understood.
Petitprez, F., Graham, N. C., Webb, S., Morrison, G., Merotto, L., Webb, J., Xie, Y., Guney, E., Weiss, W. A., Finotello, F., Kitamura, T., Pollard, S. M., P...
Focus: Local Tumor Microenvironment Niches Correlate with Survival and Immunotherapy Response in Human Glioblastoma.
Background: Glioblastoma (GBM) is an aggressive form of primary brain cancer.
Recent efforts to characterize GBM using single-cell or spatial transcriptomics have revealed tremendous intra-tumoral heterogeneity among malignant cells and across different tumor areas.
Wang, Y., Yan, X., Weiser, N. E., Wong, I. T.-L., Zhang, S., Huang, Y.-H., Li, R., Kraft, K., Gnanasekar, A., Tang, J., Chittenden, C., Bruckner, L., Noorani...
Focus: Inverted logic of ecDNA localization converts nuclear periphery into oncogenic transcription hubs in cancer.
Extrachromosomal DNA (ecDNA) is a major driver of cancer pathogenesis, however, its spatial organization in the nucleus is not currently understood.
Here we show that ecDNAs, in contrast to chromosomal DNA, preferentially localize to the nuclear periphery yet resist peripheral gene silencing.
JournalSynthetic biologyScience (New York, N.Y.)2026-09-17
Yoon PH, Loi KJ, Zhang ZT, Docter TA, Lopez SC, Langeberg CJ, Ur-Rehman MM, Vohra K, Zhou Z, Esain-Garcia I, Trinidad MI, Shi H, Boger R, Wang PY, Adler BA, ...
Focus: A noncontiguous code for RNA-guided DNA recognition at the origin of CRISPR-Cas.
CRISPR-Cas provides RNA-mediated adaptive immunity, but how its first RNA-guided effector arose is unclear.
In this study, we report the discovery of Viral Interference Programmable Repeat (VIPR) systems consisting of a Vipr protein ancestral to the earliest CRISPR-Cas effectors and VIPR RNAs…
Focus: The Virtual Biotech: A multi-agent AI framework for therapeutic discovery and development.
Drug development requires evidence integration across biological scales and modalities, but relevant tools are fragmented.
We introduce the Virtual Biotech, an organization of artificial intelligence (AI) agents modeled on a drug-development company, with agentic divisions spanning target discovery, safety assessment, modality selection, and…
Zhang Q, Zhang J, Cao W, Lu Z, Chang W, Ding H, Chen C, Li Z, Xue X, Wang S, Zhang S, Xie Y, Xia Y, Wu Q, Shui Z, Li X, Zheng Z, Zhou Y, Mok TCW, Xia Y, Wang...
Focus: An expert-level generalist AI for abdominal CT diagnosis.
Artificial intelligence (AI) in radiology aspires to deliver expert-level diagnosis across diverse clinical tasks, yet existing supervised strategies remain limited in scope.
We developed RADAR, a generalist vision-language model trained on more than 400,000 contrast-enhanced abdominal computed tomography (CT) examinations and 15 million anatomy-wise image-text pairs, learning directly from clinic.
Guo LY, Ting DSJ, Su X, Aliper A, Zhavoronkov A, Ting DSW.
Focus: Toward autonomous science with agentic artificial intelligence.
Artificial intelligence (AI) in biomedicine has evolved from pattern-recognition for medical image analysis to generative models like AlphaFold that predict protein structures.
Tools such as Elicit, GPT-Rosalind, and Claude Science now bridge prediction and reasoning through literature synthesis, domain-tuned models, and agentic workbenches.
Ning C, Wang K, Wang T, Ma J, Zhao X, Xi T, Wang Y, Cao P, Gao S, Feng X, Hu W, Wang X, Zhang F, Ren M, Wu X, Liu F, Zhang X, Zhu J, Li C, Dai Q, Dang Z, Yan...
Focus: Ancient DNA unveils distinctive ancestries in the Bronze and Iron Ages of East Tianshan.
The East Tianshan Mountains occupy a key corridor between Central and East Asia, but their population history remains poorly understood.
Here we report genome-wide data from 135 ancient individuals from 11 archaeological sites.
JournalLife scienceScience (New York, N.Y.)2026-09-17
Hurtley SM, Hessler A, Stajic J, Osborne IS, Lopez B, Fogg CN, Leder K, Ross SH, Simonti C, Smith J, Nusinovich Y, Kelly PN, Suleymanov Y, Maroso M, Jiang D,...
Focus: In Science Journals.
Highlights from the.
Science family of journals.
JournalLife scienceScience (New York, N.Y.)2026-09-17
Laun L, Leunig A, Zhang F, Akgöl S, Rossaro D, Fabritius MP, Anjum A, Kreutz L, Mackert N, Araujo GHM, Mahameed S, Balmforth C, Hoffknecht ML, Mader M, Hoffm...
Focus: Splenic regulation of systemic platelet activation state.
Platelets are essential to prevent blood loss and to orchestrate inflammation.
Thrombotic complications of vascular disease and hyperresponsive platelets are associated with adverse outcomes, yet physiological mechanisms counteracting systemic platelet activation are poorly defined.
JournalLife scienceScience (New York, N.Y.)2026-09-17
Yuan W, Zhang S, Bigagli N, Kwak H, Warner C, Karman T, Stevenson I, Will S.
Focus: Extreme loss suppression in an ultracold molecular gas with widely tunable dipolar interactions.
Ultracold dipolar molecules hold great promise for the creation of exotic quantum states of matter, but the realization of long-lived molecular bulk samples with strong dipole-dipole interactions has…
In this work, we realized a collisionally stable gas of ultracold ground state molecules with a lifetime of several seconds.
JournalLife scienceScience (New York, N.Y.)2026-09-17
Roh JD, Jun Y, Jeon H, Kim J, Yi Y, Kim M, Cho H, Oh Y, Moon H, Kim J, Kim S, Ryu J, Kang M, Kim J, Kim Y, Jung Y, Yoo T, Oh H, Kim H, Jin C, Yang Y, Choi G,...
Focus: Transcriptome-based classification in mice with ASD-risk mutations.
Autism spectrum disorder (ASD) is a neurodevelopmental condition with a strong genetic component.
Large-scale human genetic studies have identified >1200 ASD-risk genes.
JournalLife scienceScience (New York, N.Y.)2026-09-17
Previous studies of network dynamics have suggested that heterogeneity among nodes inhibits stability, which is at odds with the ubiquity of inherently heterogeneous natural and engineered systems.
Here, we show that this conclusion arises from model reductions introduced for mathematical tractability and breaks down when nodal dynamics are higher-dimensional, yielding non-Hermitian Jacobians.
JournalLife scienceScience (New York, N.Y.)2026-09-17
Maman A, Nobe Y, Fluke KA, Weidenbach K, Harte AN, Burkhart BW, Nowak J, Mukherjee P, Choudhary DK, Kustanovich A, Nir R, Vogl K, Suazo K, Radovanović D, Mat...
Focus: Phosphate backbone epitranscriptomics: Discovery of natural RNA phosphorothioates and their writer machinery.
Over 150 modifications expand the RNA alphabet, yet all known natural modifications occur on nucleobases or ribose sugars, with none identified on the phosphate backbone.
In contrast, phosphorothioates (PSs), in which a non-bridging phosphate oxygen is replaced with sulfur, are central to RNA therapeutics but have never been reliably detected in natural RNAs.
Huang X, Peng Y, Hu X, Wang Y, Zhang Z, Huang X, Luo X, Zhang S, Zhao Z, Farmer E, Hsu SK, Grover CE, Qi Z, Li L, Yang J, He Y, Chen Z, Zhang Y, Mei Y, Deng ...
Focus: 3D chromatin remodeling during domestication defines novel targets for crop improvement.
Three-dimensional (3D) genome folding shapes gene regulation, yet the genetic underpinnings linking 3D genome evolution to phenotypic innovation during domestication remain elusive.
Using population-scale Hi-C profiling of 34 semi-wild and 267 cultivated allotetraploid cottons, we generated a pan-3D genome atlas capturing extensive diversity in topologically associating domains (TADs) and chromati.
Santos, H. M., Diakova, M., Brambach, M., Anderson, C., Petrova, K., De Araujo, C. A., Simeonova, I., Almouzni, G., Peshkin, L., Abreu, J. G.
Focus: Whole-Embryo 3D Quantification Reveals Flexible Cellular Scaling and Conserved Tissue Architecture in Xenopus Species.
How embryos with markedly different absolute sizes and cell numbers establish comparable tissue organization during development remains a fundamental question in developmental biology.
To address this question, we compared two closely related Xenopus species that differ substantially in embryonic size, Xenopus laevis and Xenopus tropicalis.
Rasti-Meymandi, A., Nahali, S., Paramithiotis, E., Cheung, A. M., Dolatabadi, E.
Focus: scACORN: Context-engineered agent orchestration of specialized small language models for single-cell transcriptomic interpretation.
Single-cell atlases now exceed 66 million cells, but turning a ranked expression profile and a free-form biological question into a reliable, evidence-grounded answer remains unsolved.
Scaling a single model does not resolve this, because single-cell interpretation is a heterogeneous family of tasks whose correct answer depends on tissue, cohort, perturbation and annotation resolution.
Levesque S, Kawashima N, Hwang GH, Zeng J, Toskov V, Barry T, Mannherz W, Homfeldt L, Becerra B, Schoonenberg VAC, Pinello L, Agarwal S, Bauer DE.
Focus: Targeted genomic integration and rearrangement using prime assembly.
Although therapeutic genome editing holds great potential to remedy diverse inherited and acquired disorders, targeted installation of medium-to-large genomic modifications in therapeutically relevant cells remains challenging1.
Here we develop prime assembly, an approach that permits DNA sequence assembly and integration in human cells leveraging CRISPR-targeted dual flap synthesis.
Kaganovsky K, Kelley KW, Gschwind T, Harary PM, Kochalka J, White AD, Lerma-Usabiaga G, Chen X, Revah O, Gore F, Aoyama A, Shadrach JL, Yoon SJ, Valencia A, ...
Focus: Developmental xenocortication using human-derived organoids in mice.
The inaccessibility of human brain tissue limits the study of human development and function, a challenge that human stem-cell-derived neural models are beginning to address1,2.
Transplantation of neural organoids into rodent hosts enables the in vivo study of aspects of human neurodevelopment and circuit function, alongside behavioural phenotyping of the host animals.
Itagi P, Schuster SL, Arora S, Persse TW, Waters JA, Yang M, Min A, Chandra P, Adil M, Galipeau PC, Rudoy D, Kreitman AS, Lin Y, Ko M, Sayar E, Patton RD, Ko...
Focus: Evolution and heterogeneity of lethal metastatic bladder cancer subtypes.
Histological variation is a prognostic feature of metastatic urothelial cancer1-3, but its evolutionary trajectory remains poorly defined.
We developed a metastatic bladder cancer rapid autopsy programme enriched in histological subtypes4 to profile individuals with terminal disease.
González-Acosta D, Giménez-Llorente D, Rodrigues M, Aouami M, Barroso-Gomila O, Muñoz J, Cuadrado A, Losada A, Lopes M.
Focus: Cohesin reshapes replication fork contacts to aid fork slowing and reversal.
DNA replication forks can be challenged by cancer chemotherapeutic treatments, leading to accumulation of single-stranded DNA and slowdown of DNA synthesis.
The marked plasticity of replication forks under replication stress ensures fork stability, damage tolerance and complete genome duplication1.
St Paul M, Hendrikse LD, Ying F, Snow BE, Luo P, Helke S, Smith LK, Hilal A, Abelman DD, Ramamurthy N, Nault H, Wei EN, Gold MJ, Tobin C, Lien SC, Liu Y, Zho...
Focus: Identification of broadly tumour-reactive γδ TCRs from multiple myeloma.
γδ T cells are becoming increasingly appreciated for their antitumour capacity and role in mediating responses to immune checkpoint blockade1-3.
Unlike classical αβ T cells, the degree to which γδ T cells rely on their T cell receptors (TCRs) to induce antitumour responses remains unclear.
Focus: A thermodynamically favoured molecular computer.
Computers, like life, are usually out of equilibrium1,2.
Undesired error states are thwarted by energetically costly kinetic control processes: proofreading of biological polymers, error correction in computing and redundancy in molecular programming.
Meng Y, Mao W, Xu Z, Jia D, Lin M, Seo J, Kim B, Zhang X, Park E, Lee S, Kim J, Han S, Moon JY, Xu W, Zhang Q, He X, Chen M, Nam SH, Hu J, Kim JS, Lee S, Bae...
Focus: Heterogeneous photonic integration of single-crystalline nanomembranes.
Despite the growing maturity of silicon (Si) and silicon nitride (SiN) for integrated photonics, a single material platform is unable to meet the diversifying requirements posed for photonic…
Essential optical functionalities can be attained by the heterogeneous integration of functional materials into established photonic platforms3,4.
Stepnov AA, Werner A, Yeom SJ, Bornscheuer UT, Stahl SS, Beckham GT, Vaaje-Kolstad G.
Focus: Assessing biological degradation of non-hydrolysable synthetic polymers.
The discovery and engineering of enzymes capable of depolymerizing synthetic polymers with hydrolysable backbone linkages is now enabling biotechnological solutions for plastics recycling.
Polyolefins and other non-hydrolysable polymers, however, have saturated carbon-carbon linkages that are more challenging to cleave biologically.
Morawetz I, Riebner T, De Col LT, Schneider F, Sempelmann N, Schaden F, Bartokos M, Kazakov GA, Lahs S, Beeks K, Gerstenecker B, Grüneis A, Pimon M, Schumm T...
Focus: Continuous-wave laser absorption spectroscopy of the thorium-229 nucleus.
The low-energy nuclear transition in thorium-229 (Th-229) has been excited in thorium-doped crystals with laser light1-3, opening the path towards a highly stable and robust solid-state optical nuclear…
The required laser radiation at 148-nm wavelength has so far been produced using pulsed laser systems, in which only a small fraction of the incident photons has been…
Varilly P, Schifferli M, Yang K, Cronan P, Specht I, Burcham T, Glennon O, Jacks O, Laning E, Marrs L, Oba K, Yeung S, Zhao KW, Parker E, Omah I, Pekar JE, L...
Focus: Scalable near-real-time Bayesian phylogenetics for outbreaks with Delphy.
Pathogen genomic analysis is central to tracking, understanding and containing outbreaks1-13, but the complexity and cost of state-of-the-art phylogenetic tools limit global access and impact.
Here we introduce Delphy, an exact reformulation of Bayesian phylogenetics14-17 designed to transform its speed, scalability and accessibility while retaining Bayesian state-of-the-art accuracy.
Gopalakrishnan V, Chlorogiannis DD, Abumoussa A, Larson AM, Haouchine N, Orbach DB, Frisken S, Dey N, Golland P.
Focus: Rapid patient-specific neural networks for X-ray to volume registration.
Advanced navigation techniques in image-guided interventions and surgical robotics require the rapid and precise alignment of three-dimensional (3D) preoperative volumes (such as computed tomography and magnetic resonance imaging)…
However, existing 2D/3D registration methods fail to generalize across the broad spectrum o.
Xu X, Mailhot O, Correy GJ, Huang XP, Braz JM, Shi D, Srinivasan K, Zielinski K, Holota Y, Kuziv Y, Iliopoulos-Tsoutsouvas C, Levinzon ND, Doruk YU, Rachman ...
Focus: Development of a random background to understand ligand optimization.
Ligand optimization is central to drug discovery, with hundreds of analogues often designed and synthesized between an initial hit and a therapeutic candidate1,2.
The efficiency of this process is unclear, partly because there is no random background for optimization to compare against.
Zhang M, Castellani M, Steckenborn S, Majka M, Tsipas G, Nascimento T, Neumann U, Thangavel G, Robledillo LA, Lux T, Deberón L, Pfordt U, Campoy JA, Vijayan ...
Focus: Sex without crossovers mimics clonal reproduction in Rhynchospora tenuis.
Meiotic recombination ensures accurate chromosome segregation and promotes genetic diversity by generating crossovers between homologous chromosomes1.
Although essential in most sexually reproducing organisms, recombination is variably regulated and can be absent in some lineages, a condition known as achiasmy2.
Zhang S, Gish M, Li H, Hinds TR, Mao H, Cornell M, Silvetti M, Klucas S, Vorauer C, Mundorff CC, Yadav S, Guttman M, Zheng N.
Focus: Transcriptional activation of plant immunity by salicylic acid.
The plant defence hormone salicylic acid (SA) triggers systemic acquired resistance by signalling through its receptor, NON-EXPRESSOR OF PATHOGENESIS-RELATED GENE 1 (NPR1), leading to widespread transcriptional reprogramming1,2.
However, the molecular mechanism by which NPR1 senses SA and activates transcription remains unresolved.
Lo SW, Shivarudraiah SB, Lin ZH, Helbling P, Song L, Wang J, Nouman M, Jiang F, Stemmler G, Carretta DM, Chen MN, Zhu J, Kumar S, Wang H, Christofferson AJ, ...
Focus: Electroluminescent photoresists extending lithographic scaling to OLEDs.
The miniaturization of organic light-emitting diodes is critical for next-generation ultrahigh-resolution displays and integrated photonics1-8.
However, traditional vacuum evaporation and inkjet printing methods are incompatible with the lithographic scaling processes that underpin silicon electronics9-16, hindering true monolithic integration with complementary metal-oxide-semiconductor circuits.
Focus: Mutational constraints on RSV F and its neutralization by antibodies.
New antibodies targeting the F protein of respiratory syncytial virus (RSV) have substantially reduced infant hospitalizations1.
However, viral resistance is a concern: one antibody failed clinical trials because of a resistant strain2, and sporadic resistance mutations to the most widely used antibody (nirsevimab) have…
Dai S, Dai X, Zhang T, Qi Y, Yang X, Diao P, Ge C, Huang W, Ran J, Yang X, Zhang P, Zheng K, Wang R, Qian H, Zhang K, Wu J, Fu C, Ba Q, Min J, Wang F, Zhang Q.
Focus: Mitochondrial fission factor senses and governs ferroptosis.
Ferroptosis is a form of regulated cell death driven by iron-dependent lipid peroxidation and is implicated in diverse pathological states1-4.
Although mitochondria and other organelles are increasingly being recognized as important modulators of ferroptosis5-7, a unifying mechanism that couples organelle dynamics to ferroptotic execution has remained elusive.
Lei, J., Lemaire, L. A., Hashimoto, H., Rodman, L., Levine, M., Cao, C.
Focus: Allele-Resolved Hybrid Embryos Reveal the Fates of Regulatory Divergence.
Developmental programs can remain conserved despite extensive regulatory divergence, but how evolved regulatory differences are transmitted through embryonic lineages remains unclear.
Here we generate a time resolved, allele resolved single-cell atlas of hybrid embryogenesis between Ciona intestinalis and Ciona savignyi, enabling regulatory differences accumulated between species to be followed…
Focus: Accurate and scalable decontamination of imaging-based spatial transcriptomics via optimal transport.
Imaging-based spatial transcriptomics enables molecule-resolved profiling of gene expression and tissue organization in situ.
However, segmentation errors, transcript spillover and three-dimensional cell overlap can introduce misassigned transcripts into cell-level expression profiles, compromising biological interpretation and obscuring genuine signals.
Focus: Single-cell-resolved genome atlas of prokaryoplankton inhabiting the ocean's interior.
The ocean's aphotic interior harbors three-quarters of planktonic bacteria and archaea (prokaryoplankton), whose composition, ecology, and biotechnological potential remain poorly constrained.
To address this knowledge gap, we created Global Oceans Reference Genomes (GORG)-Dark, a dataset of 9,698 genomes from individual prokaryoplankton cells sampled unselectively across a broad range of…
Abdullah KG, Miki K, Edgar CK, Wu SA, Xiao Y, Huang YT, Drexler R, Krishna S, Puliyappadamba VT, Tay LWR, Yuan F, Savani MR, Ghoche MT, Kotermanski SE, Trayl...
Focus: Gliomas phenocopy an inborn error of metabolism to drive neuronal activity and tumor growth.
The metabolic hallmarks of high-grade glioma (HGG) are not fully understood.
Human brain tissue metabolomics revealed that the creatine synthesis pathway intermediate guanidinoacetate (GAA) accumulated ∼100-fold in HGGs relative to controls, which was caused by imbalanced activities of enzymes…
Yip MCJ, Naydenova K, Otten EG, Heatley A, Moe A, Anton L, de Los Reyes-Ramírez L, Jolin HE, Langevin F, Wiacek M, Franco C, Bertolotti A, Kukulski W, McKenz...
Focus: Quality control of glycogen through direct ubiquitylation by RNF213.
Quality control of biomolecules is vital for organismal health.
While DNA repair and protein quality control are well understood, how cells monitor other important biomolecules such as glycogen remains ill-defined.
Saarenpää S, Zivi N, Masarapu Y, Mishra LS, Rouot S, Orozco A, Herrera-Foessel SA, Ahlgren Kalman T, Liva M, Yadav S, Englund M, Street NR, Sundström JF, Gia...
Focus: Norway spruce spatiotemporal programs of conifer reproductive development.
Conifers are essential components of forest ecosystems.
however, their reproductive development remains largely understudied due to their genomes' complexity.
Walker, G. E., Macchietto, M., Reid, K., Burt, L. E., Winter, A., Pracht, S., Buettner, M., Penza, V., Yung, C., Dicovitsky, R., Kuzmik, A., Vallera, D. A., ...
Focus: Longitudinal single-cell and spatial transcriptomics reveals intratumor heterogeneity, therapeutic response, and comparative value of canine marginal zone lymphoma.
Diffuse B-cell lymphomas are the most prevalent canine hematologic malignancies, and their clinical presentation resembles that of human B-cell non-Hodgkin lymphomas (NHLs).
However, a lack of a clear subtyping framework perpetuates imprecise treatment approaches that fail to address mechanisms of therapy resistance.
Carter, K., Ogunlusi, O., Sarkar, M., Akanbi, S., Nguyen, C., Nekkanti, M., Agarwal, A., Fails, D., Nawaratna, G., Klemashevich, C., Cai, J., Boland, D. J., ...
Focus: A stromal metabolic program suppresses NK-cell immunity to drive tumor progression in HER2-low breast cancer.
Cancer-associated fibroblasts (CAFs) are major regulators of the tumor microenvironment, yet how distinct CAF states suppress innate immunity in HER2-low breast cancer remains poorly understood.
Here, we identify an S100A4-enriched CAF population that expands during HER2-low breast tumor progression and establishes a metabolically immunosuppressive niche.
Olajide, T. H., Ajagbe, M. A., Rodriguez Gonzalez, A., Ijadunola, H., Ross, C., Eisenklam, L., Swets, A., McCord, R. P.
Focus: H3K27me3 Drives Constricted Migration Induced 3D Genome Rewiring in Melanoma.
Repeated exposure of neoplastic cells to mechanical stresses during metastasis can drive stable morphological and physiological changes.
We previously showed that A375 human melanoma cells subjected to 10 rounds of constricted migration ("Bottom-10 cells") became significantly more migratory and exhibited H3K9me3 relocalization, transcriptional remodeling, and…
Focus: Integrated Spatial Metabolomics and Proteomics from the Same Tissue Section Using a Conductive ITO-PET Slide.
Integrating spatial metabolomics and spatial proteomics on the same tissue section remains challenging because matrix-assisted laser desorption/ionization mass spectrometry imaging (MALDI-MSI) and laser capture microdissection (LCM)-based proteomics impose…
Here, we developed and systematically evaluated a conductive indium tin oxide-coated polyethylene tere.
Focus: Benchmarking niche identification via domain segmentation for spatial transcriptomics data.
Tissue niches are spatially organized microenvironments in which coordinated multicellular interactions shape cellular states and biological functions.
Currently, niche identification is routinely performed using domain segmentation frameworks.
Xavier A, Kolling M, Bourke AM, Mosler T, Prieto-Garcia C, Karaulanov E, Reissland M, Tassetto M, Kim D, Klaassen K, Grikscheit K, Torbica E, Dederer V, Busa...
Programmed ribosomal frameshifting (PRF) is a conserved viral strategy for expressing polyproteins from compact genomes.
Although PRF is traditionally viewed as a structural mechanism, here we show that it functions as a regulatory signal that rewires host translation in favor of viral replication.
Tretyachenko V, Leiman T, Morgenstern D, Levin Y, Asraf O, Dahan O, Dahary D, Pilpel Y.
Focus: Encoded and non-genetic protein variants expand human functional proteome.
Each stage of the Central Dogma contributes to proteome diversity through mechanisms such as heterozygosity, somatic mutations, transcriptional errors, and translational errors.
As a result, a diverse array of protein variants can coexist within a single proteome, such as that of humans.
Ng C, Fung TS, Li D, Kropp KN, Somarribas Patterson LF, Markovitz A, Weinberg DN, Jones O, Kim JY, Zhang G, Koche R, Monetti M, Tang H, He Y, Xu Z, Cai X, Yu...
Focus: Mitochondrial ATP promotes T cell differentiation through chromatin accessibility.
Immune elimination of chronic infection or cancer requires cytotoxic CD8 + T cells that adopt and maintain an effector phenotype.
Cytotoxic T cell function is a bioenergetically demanding process.
JournalLife scienceScience (New York, N.Y.)2026-09-11
In July, the prediction market platform Kalshi and data company AppliedXL began a pilot market listing binary, yes-or-no contracts on whether named late-stage clinical trials meet their preregistered…
Focus: Metax enables accurate cross-domain taxonomic profiling of metagenomes.
Taxonomic profiling is fundamental to microbiome research, yet achieving high species-level accuracy remains challenging for complex communities that span bacteria, viruses, eukaryotes, and archaea, and these limitations are…
We introduce Metax, a cross-domain taxonomic profiler that integrates coverage-based probabilistic modeling with an expecta.
Wiesbeck M, Alard EL, Merino F, Chowdhury N, Egert L, Danese A, Imhof S, Iraci Borgia M, Rajan A, Fernandez-Novel Marx N, Kepesidis E, Köferle A, Cerron-Alva...
Focus: Manipulation of protein translation and stem cell self-renewal by CRISPR activation of rRNA transcription.
Ribosomal RNA (rRNA) transcription rates vary during development, and their dysregulation is linked to diseases such as cancer and ribosomopathies.
Owing to their high abundance and genomic redundancy, the functional significance of rRNA levels remains unclear.
Jiménez-Sandoval P, Kentish O, Broyart C, Lee HK, Culjak K, Osswald U, Aitouguinane M, Tettamanti E, Schmidli M, Zhang L, Maier LP, Roussin-Léveillée C, Berl...
Focus: Glycan recognition by a plant damage-sensing immune receptor.
Pathogens target and degrade the extracellular matrix surrounding plant cells.
A central question is how cell wall-derived damage-associated molecular patterns (DAMPs) are recognized and integrated to trigger immune responses.
Curtin MC, Jackson AE, Lee MD, Brown EA, Maschek JA, Lum DH, Cox JE, Welm AL, Hilgendorf KI.
Focus: Lean adipocyte oxylipin signaling restrains breast cancer through ferroptosis.
Obesity increases breast cancer risk and tumor aggressiveness, yet the mechanisms underlying this association remain unclear.
In this work, we identify a tumor-suppressive lipid signaling pathway in which mammary adipocytes secrete the oxylipin 9S-hydroxyoctadecadienoic acid (9S-HODE).
Wenger A, Vannier JB, Lee-Six H, Loesch R, Emanuelli G, Dave M, Layeghifard M, Lawson ARJ, Abascal F, Nicola PA, Treger TD, Ogbonnah T, Parks C, Oliver TRW, ...
Focus: Extensive and differential platinum chemotherapy mutagenesis in livers of children.
Childhood cancer survivors often experience late adverse effects that may be linked to chemotherapy mutagenesis.
We studied chemotherapy mutagenesis in normal pediatric tissues using duplex sequencing (NanoSeq) to enable the detection of mutations from single DNA molecules.
Zhou H, Terbeck L, Berical A, Brunet M, Lange SM, Anderson JR, Olbrich H, Bracht DC, Wohlgemuth K, Rieck C, Raidt J, Klingauf J, Sutharsan S, Mussaffi H, Pra...
Focus: In situ structure of the human ciliary transition zone links linker defects to primary ciliary dyskinesia.
The ciliary transition zone (TZ) regulates ciliary proteome composition, yet its molecular architecture, protein content, and contribution to motile ciliopathies remain poorly defined.
We applied in situ cryo-electron tomography and subtomogram averaging to human multiciliated epithelial cells.
JournalLife scienceScience (New York, N.Y.)2026-09-10
Lei XL, Ruan J, Liang X, Teixeira R, Zhang J, Gilardet A, Zhou X, Han Y, Zhao Z, Yue HY, Kozlikin M, Vasiliev S, Medvedev S, Kruskop S, Xing S, Wang T, Basov...
Focus: Paleogenomics and habitat modeling reveal temperate Eurasian origins of woolly rhinoceroses.
The woolly rhinoceros was a prominent Ice Age megafaunal species, and there is limited knowledge regarding its origin and responses to past glacial cycles.
We sequenced 29 mitochondrial and 14 nuclear genomes from Pleistocene specimens across Eurasia and modeled the species' habitats over the past 500,000 years.
JournalLife scienceScience (New York, N.Y.)2026-09-10
Ma Q, Yang J, Li J, Zhao Z, Yue F, Yang J, Zhao S, Sheng W, Wang T, Zhao S, Zhou J, Xu W, Lu Y, Wu K, Han X, Jia X, Yang W, Wang Q, Li Y, Zhao Z, Han Y, Sun ...
Focus: Open framework-based Brønsted acid-Lewis base interfaces boost proton transfer in the fuel cells.
Limited proton conductivity within the catalyst layer induces severe ohmic polarizations and constrains power output at high hydrogen-to-electricity efficiencies in proton exchange membrane fuel cells.
We demonstrate that proton transfer can be boosted by constructing Brønsted acid-Lewis base interfaces through integrating organic open frameworks with Nafion.
JournalLife scienceScience (New York, N.Y.)2026-09-10
Li J, Turaev M, Matsubara M, Kliemt K, Krellner C, Pal S, Fiebig M, Kroha J.
Focus: Discovery of an intrinsic non-Hermitian phase transition in a bulk condensed-matter system.
Across regular phase transitions, systems remain in thermal equilibrium.
However, when a system is driven far from equilibrium, non-Hermitian phase transitions may arise where the dynamical behavior-rather than steady properties-undergoes a qualitative change at a critical, so-called…
JournalLife scienceScience (New York, N.Y.)2026-09-10
Simonti C, Lopez B, Nusinovich Y, Smith KT, Sirois C, Szuromi P, VanHook A, Rubenstein DR, Kelly PN, Huang J, Smith J, Hurtley SM, Ray LB, Stajic J, Bere L.
Focus: In Science Journals.
Highlights from the.
Science family of journals.
JournalLife scienceScience (New York, N.Y.)2026-09-10
Cabon A, Fonti P, von Arx G, Biondi F, Camarero JJ, Campelo F, Carrer M, Čufar K, Cuny H, Deslauriers A, Fajstavr M, Fonti M, Frank D, Giovannelli A, Gruber ...
Focus: Growth rate overrides the benefit of extended growing season from boreal to semiarid conifers.
Climate warming lengthens the productive season in extratropical forests.
Yet there is inconclusive evidence on whether this in turn elicits enhanced tree growth and forest carbon sequestration.
JournalLife scienceScience (New York, N.Y.)2026-09-10
Wang Y, Zhao Y, Zhang Y, Zhang L, Zhong Z, Liu S, Hou C, Liu F, Zhang BB, Wei Z, Liu YY, Wang H, Tan PH, Wu J.
Focus: Giant tunneling electroresistance in sliding ferroelectrics.
Nonvolatile memories should store information reliably while consuming little energy.
Ferroelectric tunnel junctions offer compact readout, but conventional ionic displacement ferroelectrics can fatigue, and two-dimensional sliding ferroelectrics are robust but generate weak readout in two terminal devices.
Song JH, Friedmann D, Wu Y, Moses A, Baruni JK, Yuan Y, Rana I, Zhao K, Hindmarsh Sten T, Wang Q, Xiao SA, Chen X, Linderman SW, Luo L.
Focus: Architecture of the serotonergic projectome in the mouse brain.
The serotonin system innervates nearly the entire brain to support diverse functions, and its dysfunction is implicated in multiple psychiatric disorders.
Although recent studies suggested that this anatomically diffuse system supports differentiated rather than uniform modulation, its overall organization is unclear.
The spatial organization of membrane proteins is an underexplored dimension of cell surface biology 1,2.
Spatial proximity shapes cellular function and therapeutic targetability 2,3 , yet efforts to identify tumour-associated antigens (TAAs) have largely focused on expression alone 4.
van Krimpen A, Huang J, Eterman M, Gerretsen V, Umetani M, Janssen JC, van Nimwegen M, Rozendaal N, van den Bosch TPP, Jiang X, Logronio K, Liu AZ, Liu YR, N...
Focus: PLA2G2D in tumour-draining lymph nodes regulates anti-tumour immunity.
Systemic anti-tumour immunity results from T cell priming in tumour-draining lymph nodes (TDLNs) 1-4.
Although the suppression of T cells in tumours is well characterized 5-8 , whether this occurs in TDLNs-and if so, through which mechanisms-remains poorly understood.
Jerabek S, Jung C, Kappy M, Zhao Q, Sung J, Wang N, Kim E, Kim J, Kulmann MIR, King MB, McAndrew MJ, Li M, Bhatele S, Isado M, Jang HS, Dolezal M, Prosser R,...
Focus: Highly efficient base editing at PCSK9 and normal human embryo development.
Cas9-based tools enable programmable DNA lesions for studying repair outcomes, gene function, and genome correction.
In human embryos, Cas9-induced DNA double-strand breaks are genotoxic, causing frequent aneuploidy and large deletions 1,2.
Sun R, Qian L, Li Y, Liu T, Cheng H, Zhang X, Zhou X, Zhan Y, Zhang G, Luo Z, Ma K, Wu C, Ji D, Xue Z, Meng H, Xiang Y, Lei D, Zhou Q, Hu W, Deng Y, Tan L, X...
Focus: An operational perturbation proteomics-based virtual cell model.
Artificial intelligence-empowered virtual cell models represent an emerging approach for in silico drug discovery 1-3 , yet most existing approaches lack large-scale, time-resolved perturbation proteomics data and interpretable…
Here we generated more than 38 million temporal protein-abundance measurements from systematically perturbed breas.