Trinh Phan-Canh

PhD Student at Kuchler lab, Max Perutz Labs Vienna, Vienna BioCenter
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I have been studying clinical fungal infections for 4 years in Vietnam before starting research in fungal pathogenesis and drug-resistance mechanisms in Vienna. My PhD project focuses on Candida auris, an emerging human fungal pathogen causing invasive infections in immunosuppressed patients with a high rate of pan-antifungal drug resistance.

I apply integrated omics datasets (RNA-seq, ATAC-seq, proteomics, metabolomics) and tools of reverse genetics (targeted gene disruption, insertions of reporter genes) to

  • dissect dynamics of regulatory networks and chromatin alterations in morphogenetic switching, host-fungal interaction, and drug response;
  • identify virulence factors and antifungal drug resistance genes.

The long-term goal is discovering the major mechanisms of virulence and drug resistance of C. auris to develop better therapeutic strategies.

Papers

A Proteomic Approach for the Quantification of Posttranslational Protein Lysine Acetylation in Candida albicans

Transcriptomics and Phenotyping Define Genetic Signatures Associated with Echinocandin Resistance in Candida auris

Synthesis and anti-Staphylococcus aureus activity of 2-pyrazoline and 2-isoxazoline derivatives

DPPH-Scavenging and Antimicrobial Activities of Asteraceae Medicinal Plants on Uropathogenic Bacteria

Synthesis and evaluation of antibacterial and antifungal activities of some hydrazone derivatives of chalcones

Identification of Acinetobacter baumannii and detection of ß – lactam antibiotic resistance genes in clinical samples by multiplex PCR

Damar Batu Essential Oil - In Vitro Antimicrobial Activities and Perspectives

Isolation and screening antimicrobial activity of soil actinobacteria

In vitro susceptibility testing of dermatophytes isolated from hospital of dermatovenereology in Ho Chi Minh city to ketoconazole and terbinafine

Dirinaria applanata - morphology, chemical composition and antimicrobial activity

Study on fermentation conditions for Bacillus subtilis KP3 spores production activity

Posts

Poster Presentation at The Vienna Biocenter PhD Symposium 2022 ‘Pushing Boundaries’

Trinh participated in the ASEAN's 55th year founding anniversary at the United Nations office in Vienna

Two collaboration works were released in August

Oral presentation at The 1st Scientific Seminar of Young Vietnamese Intellectuals

Yeast Genetics Meeting 2022

Welcome

Poster Presentation at FEBS-HFP2022